© 2020 MJH Life Sciences and Cancer Network. 7. Keep red clover leaf extract out of the reach of children and away from pets. Potential uses: Red clover is used to treat menopausal symptoms and breast pain. 1999;84:895-98. Acute-on-chronic subdural hematoma in a patient taking Red Clover herbal supplement: A case report. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. All rights reserved. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Red clover does not significantly reduce total or LDL cholesterol, or increase HDL in women 49-65. Red clover may interfere with hormonal therapy drugs. In addition, it protected dopaminergic neurons against lipopolysaccharide-induced damage by inhibiting microglial activation and proinflammatory factors (3). It is unclear whether red clover is safe for consumption by women with a history of estrogen-receptor (ER) positive cancer. The plant was thought to purify the blood by promoting urine and mucus production, improving circulation, and stimulating secretion of bile. Dietary isoflavone intake also improved arterial compliance, an index of large artery elasticity which is an important cardiovascular risk factor (12). Cattle and other animals graze on red clover. Hidalgo LA, Chedraui PA, Morocho N, et al. No one with a hormone sensitive condition such as uterine cancer, breast cancer, ovarian cancer, uterine fibroids, or endometriosis, should use red clover. Red clover is a wild plant belonging to the legume family.  However, the red clover isoflavone biochanin A was shown to inhibit aromatase activity and expression, thereby conferring a protective effect. Biochanin A (BCA) is a dietary isoflavone present in red clover. Red clover supplements are available as capsules, tablets, tinctures, and teas. Am J Clin Nutr. It has also been used medicinally to treat several conditions including cancer, whooping cough, respiratory problems, and skin inflammations, such as psoriasis and eczema. Your generosity makes this possible. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. Cancer: Red clover has been studied for its ability to inhibit the growth of new blood vessels to tumours. This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. Three: Blood flow seems to be enhanced by this herb since it can help prevent blood clots and thins the blood. Red Clover Basics. Red clover is a wild plant belonging to the legume family. Anticoagulants / Antiplatelets: Preclinical studies suggest red clover may increase their effects (20). 2012 Jan;28(1):29-33. doi: 10.3109/09513590.2011.579660. And they are going to start consuming it in very large amounts! Regardless of the myths and folktales surrounding red clover, one thing has been proven through time - the herb makes a powerful addition to your natural medicine arsenal. The relation between red clover and cancer is not been fully discovered yet. Red clover is used in the treatment of skin complaints (especially eczema and psoriasis), cancers of the breast, ovaries and lymphatic system, chronic degenerative diseases, gout, whooping cough and dry coughs. Subarachnoid hemorrhage was reported in a 53-year-old woman following use of an herbal supplement that contained red clover, dong quai, and Siberian ginseng, which she took for hot flashes associated with perimenopause. This Web site — Information About Herbs, Botanicals and Other Products — is for general health information only. In one case, the issue resolved after supplement discontinuation. Red Clover roots have also been used to treat diphtheria. Red clover is a wild plant belonging to the legume family. One: The isoflavones that are contained in the herb may help raise HDL cholesterol (the good kind).  Further research is needed to determine the safety and efficacy of this agent. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. Compounds in red clover include phytoestrogenic isoflavones such as genistein, diadzen, formononetin and biochanin A. The isoflavones present in red clover have estrogen-like effects and have been the subject of intense research over the last decade. Red clover traditional medicine uses. Of concern are findings that red clover inhibits the growth of normal prostate cells and increases resistance of prostate cancer cells to high-dose radiation in vitro (15). Red clover contains substances called isoflavones. Therefore, patients with estrogen receptor-positive cancers or undergoing radiotherapy for prostate cancer should avoid using red clover. Red clover is a perennial herb traditionally used to treat skin conditions such as... ALSO KNOWN AS: . 2007;14:153-59. Red clover has long been used as a “blood purifier,” specifically for the potential treatment of cancer. Red Clover Benefits: as a Phytoestrogen. 3. van de Weijer PH, Barentsen R. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Today, extracts from red clover are most often promoted for menopause symptoms, high cholesterol levels, or osteoporosis. However, compared to estrogen, which has relative high binding affinity for the ER-α and ER-β, isoflavones demonstrate up to ~1600 times lower affinity for ER-α meaning they should not increase the risk of cancer. Red clover is a favorite herb for women experiencing hot flashes and other hormonal changes throughout menopause, including vaginal dryness and osteoporosis. Lukaczer D, Darland G, Tripp M, et al. German Mennonites took the plant over with them to America and it is still used to help treat whooping cough, croup and to give support in some cancers. Studies of individual components of red clover show some cancer fighting action in vitro . Overuse of isoflavone supplements can increase the risk of hormone-sensitive cancer. Red clover is a reserve of protein and unique phytochemicals. Epub 2011 May 26. Red clover has also been contraindicated with heparin, ticlopidine, and warfarin, based on its coumadin content. 11. The treatment of cancer with Red Clover has a great many advocates and has been with us for a long time. Red clover does not seem to reduce menopausal symptoms. Among classic herbalists, red clover is known as one of the world’s oldest and most common natural herbal supports for the treatment for all varieties of cancer — anywhere in the body. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Red clover contains substances called isoflavones. Si vous êtes en période de ménopause, vous avez peut-être envisagé les thérapies hormonales afin de réduire les symptômes les plus gênants. The isoflavone Biochanin A inhibited activity and gene expression of aromatase, an enzyme that catalyzes the conversion of androgen to estrogen (2). Data on red clover’s potential for reducing the symptoms of menopause and for decreasing the risk of breast cancer are inconclusive. Red clover contains the anticoagulant and blood-thinning compound coumarin. Prostate-specific natural health products (dietary supplements) radiosensitize normal prostate cells. Red clover is also a source of many valuable nutrients including calcium, chromium, magnesium, niacin, phosphorus, potassium, thiamine, and vitamin C. The phytoestrogenic properties of the isoflavones in red clover are why it is not recommended for use by women who’ve been diagnosed with breast cancer, without first discussing it with their physician. 2002;42:187-93. Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials. Downsides and side effects Side effects. . But as you can see hormone support for her helps in treating cancer such as breast cancer if used before actually getting the cancer. It also stopped the growth of normal prostate cells and increased prostate cancer cell resistance to high-dose radiation. 9. Preclinical studies suggest red clover extract may act as an estrogen agonist and stimulate proliferation of ER-positive breast cancer cells (1). However, its usage in many parts of the world as a traditional cancer remedy has prompted scientists to take a close look at the herb. It has also been used medicinally to treat several conditions including cancer, whooping cough, respiratory problems, and skin inflammations, such as psoriasis and eczema. Data on red clover’s potential for reducing the symptoms of menopause and for decreasing the risk of breast cancer are inconclusive. Case reports Isoflavones are phytoestrogens—compounds similar to the female hormone estrogen. Bleeding disorders: Red clover might increase the chance of bleeding. Another recent study found that red clover inhibited the growth of normal prostate cells and increased the resistance of prostate cancer cells to high-dose radiation in vitro. There is no evidence that red clover can help treat cancer. Red clover contains isoflavone compounds similar to those found in soy. In the best selling herbal classic Back to Eden, author Jethro Kloss declares red clover as a life-saving anti-cancer remedy. Topical use of red clover includes for cancer, skin sores, burns, sore eyes, and chronic skin diseases including eczema. Cow clover, wild clover, purple clover, beebread, cow grass, meadow clover, purple clover. Now before going any further, I know that some of you object to using a phytoestrogen for prostate cancer. Red clover has similar effects to estrogen and could complicate these conditions and interfere with treatment. The red clover plant actually belongs to the legume plant family (just like peanuts and beans), which is why animals often graze on it in the wild. In postmenopausal women, supplementation alleviated vasomotor and menopausal symptoms (18) (25). Recent findings from a preclinical study suggest that red clover may increase resistance of prostate cancer cells to high-dose radiation while inhibiting the growth of normal prostate cells. Here are a few of the most common uses. This not only helps to reduce growth of tumours but can also work to shrink them. Red clover leaf extract is to be used only by the patient for whom it is prescribed. In red clover blossoms, the compounds biochanin-A, caffeic acid, chlorogenic acid, coumarin, formononetin, genistein and isorhamnetin all demonstrate some anti-cancer … Red Clover is one of the ingredients s of the ‘controversial Hoxsey cancer treatment,’ developed by Harry Hoxsey in the 1920’s. Cattle and other animals graze on red clover. Otherwise there is no stand Neurocrit Care. Red clover has been claimed to be effective for treating hormonally driven cancers and for reducing hot flashes in women who experience premature menopause as part of their cancer treatment. After postoperative re-hemorrhage, an intraoperative thromboelastogram confirmed that antiplatelet effects were more likely than coumarin toxicity. Red clover has also been contraindicated with heparin, ticlopidine, and warfarin, based on its coumadin content. Le Bail JC, Champavier Y, Chulia AJ, Habrioux G. Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells. Patients should consult with their physicians before taking red clover supplements. Patients with hormone-sensitive cancers should avoid red clover because it has estrogenic activity, Red clover may increase effects of anticoagulants and antiplatelet drugs, Red clover causes toxic effects when used with methotrexate, © 2020 Memorial Sloan Kettering Cancer Center, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Integrative Medicine at Home Membership Program. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Red clover is an herbal supplement used orally for conditions such as menopausal symptoms and hot flashes, mastalgia, premenstrual syndrome, cancer prevention, indigestion, hypercholesterolemia, whooping cough, asthma, bronchitis, and sexually transmitted diseases.. Topical use of red clover includes for cancer, skin sores, burns, sore eyes, and chronic skin diseases including eczema. It contains compounds known as isoflavones that act as phytoestrogens. However, unless red clover herb is fermented, it is unexpected to have any anticoagulant effects. 2007;7:76-80. Russian folk healers and traditional Chinese physicians have long used Red Clover for asthma, bronchitis and to clear the lungs. From radiation therapy to clinical trials to check-ins with your doctor, your care is made as convenient as possible. The June 2004 edition of Breast Cancer Research states that red clover does not cause any oestrogenic increase in breast density, while human and synthetic oestrogen does. 10. Isoflavones are phytoestrogens—compounds similar to the female hormone estrogen. Cuts down on the risk of breast cancer. The flower is also used for inflammatory conditions associated with arthritis and gout. Please keep in mind that clinical studies have shown that some phytoestrogens have anti-cancer properties. Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial. It’s possible that this herb may complicate these conditions and interfere with treatments, or even worse potentially raise the risk for them developing in the first place. 6. Red clover (Trifolium pratense L.) is a plant in the Fabaceae botanical family. Red clover extract can stimulate the production of estrogen receptor-positive breast cancer cells in lab experiments. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins.